![]() ![]() Individuals with asthma or other lung problems may be advised to avoid tramadol. This problem, called respiratory depression, causes breathing to become slow and shallow. Although the risk is less with tramadol than with other opioids, such as morphine, some people who take the medication may develop a breathing problem. Signs of serotonin syndrome should prompt an immediate call to the doctor or a visit to the emergency room. Symptoms include shivering, muscle stiffness, confusion, and a high fever. The syndrome can be fatal, but often the symptoms go away when the medication is stopped. This condition is classified as a group of symptoms that occur when the body’s levels of serotonin are increased. People taking tricyclic compounds, such as cyclobenzaprine, promethazine, and tricyclic antidepressants (TCAs).Those taking antidepressants or appetite suppressants.People taking selective-serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitors (SNRIs).Individuals with a recognized risk for seizure (such as head trauma, metabolic disorders, alcohol and drug withdrawal, and central nervous system infections).Additionally, other factors that can increase the risk of seizure include, but are not limited to: While a seizure can occur while taking the recommended dose, seizures are more likely in those who have taken high doses of tramadol or combined tramadol with other medications. Seizures are among the most serious potential problems associated with tramadol. Tramadol is associated with a number of risks that can be life threatening if not treated appropriately. Possible Health Risks Associated with Tramadol Tramadol: Potential Side Effects, Interactions, Risks, and Complications Older adults tend to process medications differently and should be especially cautious when taking tramadol. Combining tramadol with alcohol, sedatives, or other opioid medications can also lead to serious medical complications, including overdose. Drug and supplement interactions with tramadol can be life-threatening. Keeping the prescriber and pharmacist informed about all other medications and supplements being taken is crucial when taking tramadol. People who are suicidal or prone to addiction should not take tramadol. The health care provider should also be informed if the person is pregnant or breastfeeding. Any current or past drug or alcohol abuse.Patients are encouraged to answer their health care provider’s questions honestly and notify them of the following: Potential Interactions and ComplicationsĬertain conditions could increase the risks of complications. Seek medical attention if they increase or do not go way. These side effects are typically mild and may go away within a few days or weeks. And since it must pass through the liver to reach full effect, users do not transition to snorting or injecting.As with most medications tramadol may have side effects. But tramadol, one recent survey suggests, might naturally deter that trajectory because as doses increase, nasty side effects become more pronounced. As people begin to abuse most opioids, they move to higher doses, then to snorting or shooting up as they build up tolerance and no longer feel the same high from the same dose. Grunenthal, the German pharmaceutical company that originally synthesized tramadol, also points to its strange chemistry to defend its claim that the drug is less prone to be abused. Studies suggest nearly 30% of North Africans metabolize tramadol to the most active opioid potency, she said, compared with about 1 percent of northern Europeans. In a cruel twist, those groups are largely clustered in the areas that lack access to other opioid medications, so are dependent on tramadol for pain relief: Africa, the Middle East and parts of Asia. Research has shown that some ethnic groups are prone to process tramadol as a far more potent opioid, upping the risk of addiction, Madras said. ![]()
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